Severe Asthma Research Program    (SARP)
A National Institutes of Health/ National Heart, Lung & Blood Institutes
sponsored network

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SARP  Publications  

NEW!  Recent publications added 01/15/2011 (shown in green)


Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma
Research Program.
  Gamble C, Talbott E, Youk A, Holguin F, Pitt B, Silveira L, Bleecker E, Busse W, Calhoun W, Castro M, Chung KF, Erzurum S, Israel E, Wenzel S. J Allergy Clin Immunol. 2010 Nov 2. [Epub ahead of print] PubMed PMID: 21051082.

Mast Cell Phenotype, Location and Activation in Severe Asthma. Data from The Severe Asthma
Research Program.
 Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW, Castro M, Gaston B, Israel E, Schwartz LB, Curran-Everett D, Moore CG, Wenzel SE.
Am J Respir Crit Care Med. 2010 Sep 2. [Epub ahead of print] PMID: 20813890.

Determinants of exhaled breath condensate pH in a large asthma population Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, Jarjour WN, Moore W, Peters SP, Wenzel S, Hunt JF, Gaston B; for the National Heart Lung Blood Institute Severe Asthma Research Program (SARP).Chest. 2010 Oct 21. [Epub ahead of print] PubMed PMID: 20966042.

Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived
cytokines.
 Brasier AR, Victor S, Ju H, Busse WW, Curran-Everett D, Bleecker E, Castro M,
Chung KF, Gaston B, Israel E, Wenzel SE, Erzurum SC, Jarjour NN, Calhoun WJ.
Clin Transl Sci. 2010 Aug;3(4):147-57. PubMed PMID: 20718815.

Levels of nitric oxide oxidation products are increased in the epithelial lining
fluid of children with persistent asthma.
 Fitzpatrick AM, Brown LA, Holguin F, Teague WG; National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program.  J Allergy Clin Immunol. 2009 Nov;124(5):990-6.e1-9. PubMed PMID: 19895987

Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC. Am J Respir Crit Care Med. 2010 Feb 4. PMID: 20133930

Identification of asthma phenotypes using cluster analysis in the severe asthma research program.  Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER. Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-323. Epub 2009 Nov 5. PMID: 19892860


Airway glutathione homeostasis is altered in children with severe asthma: Evidence for oxidant stress
. Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA. J Allergy Clin Immunol. 2009 Jan;123(1):146-152.e8. PMID: 19130935

Alterations of the arginine metabolome in asthma. Lara A, Khatri SB, Wang Z, Comhair SA, Xu W, Dweik RA, Bodine M, Levison BS, Hammel J, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Peters SP, Teague WG, Wenzel S, Hazen SL, Erzurum SC. Am J Respir Crit Care Med. 2008 Oct 1;178(7):673-81. Epub 2008 Jul 17. PMID: 18635886


Airway lipoxin a4 generation and lipoxin a4 receptor expression are decreased in severe asthma.  Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD. Am J Respir Crit Care Med. 2008 Sep 15;178(6):574-82. Epub 2008 Jun 26. PMID: 18583575


A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Busacker A, Newell JD Jr, Keefe T, Hoffman EA, Granroth JC, Castro M, Fain S, Wenzel S. Chest. 2009 Jan;135(1):48-56. Epub 2008 Aug 8. PMID: 18689585


Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Aysola RS, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, Zheng J, Schechtman KB, Ramkumar TP, Cochran R, Xueping E, Christie C, Newell J, Fain S, Altes TA, Castro M. Chest. 2008 Dec;134(6):1183-91. Epub 2008 Jul 18.  PMID: 18641116 


Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Bhavsar P, Hew M, Khorasani N, Torrego A, Barnes PJ, Adcock I, Chung KF. Thorax. 2008 Sep;63(9):784-90. Epub 2008 May 20.  PMID: 18492738 


Reply to Macklem and Irvin; Ronald L. Sorkness; J Appl Physiol 105: 393, 2008;doi:10.1152/japplphysiol. 90623.2008


Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma.  Fitzpatrick AM, Holguin F, Teague WG, Brown LA. J Allergy Clin Immunol. 2008 Jun;121(6):1372-8, 1378.e1-3. Epub 2008 Apr 16. PMID: 18417198 


Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage–derived cytokines. Brasier AR, Victor S, Boetticher G, Ju H, Lee C, Bleecker ER, Castro M, Busse WW, Calhoun WJ. J Allergy Clin Immunol. 2008 Jan;121(1):30-37.e6. PMID: 18206505


Epithelial cell proliferation contributes to airway remodeling in severe asthma. Cohen L, E X, Tarsi J, Ramkumar T, Horiuchi TK, Cochran R, DeMartino S, Schechtman KB, Hussain I, Holtzman MJ, Castro M. Am J Respir Crit Care Med. 2007 Jul 15;176(2):138-45. Epub 2007 Apr 26. PMID: 17463414


IL-4r alpha mutations are associated with asthma exacerbations and mast cell/ige expression. Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum S, Gaston B, Israel E, Teague WG, Curran-Everett D, Meyers DA, Bleecker ER.  Am J Respir Crit Care Med. 2007 Mar 15;175(6):570-6. Epub 2006 Dec 14. PMID: 17170387


Airway nitric oxide release is reduced after PBS inhalation in asthma. Shin HW, Shelley DA, Henderson EM, Fitzpatrick A, Gaston B, George SC. J Appl Physiol. 2007 Mar;102(3):1028-33. Epub 2006 Nov 16. 
PMID: 17110506

Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. DNA Seq.  Smith RS, Meyers DA, Peters SP, Moore WC, Wenzel SA, Bleecker ER, Hawkins GA.  2007 Feb;18(1):47-53. PubMed PMID: 17364813

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peters SP, Teague WG, Meyers DA, Busse WW, Wenzel SE. J Allergy Clin Immunol. 2007 Feb;119(2):405-13. PMID: 17291857

 

Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide. Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG. J Allergy Clin Immunol. 2006 Dec;118(6):1218-25. Epub 2006 Oct 10. PMID: 17157650

 

Buffering airway acid decreases exhaled nitric oxide in asthma. Gaston B, Kelly R, Urban P, Liu L, Henderson EM, Doctor A, Teague WG, Fitzpatrick A, Erzurum S, Hunt JF. J Allergy Clin Immunol. 2006 Oct;118(4):817-22. Epub 2006 Sep 1. PMID: 17030232

 

Regional fibroblast heterogeneity in the lung implications for remodeling. Kotaru C, Schoonover KJ, Trudeau JB, Huynh ML, Zhou X, Hu H, Wenzel SE. Am J Respir Crit Care Med. 2006 Jun 1;173(11):1208-15. Epub 2006 Mar 16. PMID: 16543551


Diminished lipoxin biosynthesis in severe asthma. Levy BD, Bonnans C, Silverman ES, Palmer LJ, Marigowda G, Israel E. Am J Respir Crit Care Med. 2005 Oct 1;172(7):824-30. Epub 2005 Jun 16.PMID: 15961693


Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Comhair SA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, Gaston B, Hastie A, Hew M, Jarjour N, Moore W, Peters S, Teague WG, Wenzel SE, Erzurum SC. Am J Respir Crit Care Med. 2005 Aug 1;172(3):306-13. Epub 2005 May 5. PMID: 15883124 
 

Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats. Sorkness RL, Remus JL, Rosenthal LA. J Allergy Clin Immunol. 2004 Nov;114(5):1027-32.PMID: 15536405

 

 

 

 


 

 




 

 

 

 



 

 

 

 

 

 

 

 

 






 

 



 

 



 

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