Severe Asthma Research Program    (SARP)
A National Institutes of Health/ National Heart, Lung & Blood Institutes
sponsored network

Your Subtitle text
Universty of Wisconsin              Information for Asthmatics and caregivers

We have shown that patients with severe asthma have more air trapping, or too much air left in the lungs at end of breath, compared to those with non-severe asthma. Airway imaging such as CT scan or MRI has shown irregular airway patterns and air trapping in the lungs. Some of these irregular airway patterns are long lasting. Others may start with viral asthma exacerbations/attacks or a lung challenge (allergens or chemicals), resolve, and then occur again in the same general areas on repeated exposures. This suggests an airway problem in a specific airway. In initial studies, markers of inflammation tended to be more important in lung segments that showed these irregular patterns on imaging. In other studies, we showed that young children with repeat severe wheezing episodes have lower lung function in later childhood, a similar pattern in other studies of adults and children with asthma.

Therefore, we will test if severe asthma exacerbations, in some patients, lead to the development irregular airway patterns and high levels of airway inflammatory cells in specific areas of the lung that may persist over time. These areas in the lung may have more airway damage leading to poor lung function, increased air trapping, and more severe asthma. The project at UW Madison will focus on looking at those irregular airway patterns through lung imaging and studies of inflammation at an individual’s baseline (usual level of symptoms) and during a time of exacerbation.

Site Investigators and Locations:


Nizar Jarjour, M.D.; Principal Investigator     
Adult Pulmonologist
University of Wisconsin-Madison
Madison, Wisconsin   53792


Loren Denlinger, M.D., Ph.D.; Co-investigator
Adult Pulmonologist
University of Wisconsin-Madison
Madison, WI 53792

Sean Fain, Ph.D.; Co-investigator     
Associate Professor, MRI Imaging
University of Wisconsin-Madison
Madison, WI 53792

Ronald L. Sorkness, Ph.D., R.Ph.; Co-investigator
Professor of Pharmacy
University of Wisconsin-Madison
Madison, WI 53792

Site Coordinator Contact:

Holly Eversoll                         

University of Wisconsin-Madison
Clinical Research Coordinator
Asthma, Allergy, & Pulmonary
(608) 263-0524

Interested in Participating in SARP?

You will likely qualify for participation in SARP as a severe asthmatic if you:
1.    Have been diagnosed with asthma by a physician
2.    Require high  or continuous doses of asthma medications, such as Advair, Symbicort, prednisone or medrol
3.    Still have asthma symptoms on a regular basis
4.    Have had frequent or severe exacerbations of asthma (requiring prednisone,  ER visits, hospitalizations)
5.    Are not currently smoking and have smoked less than 5-10 years total
6.    Are between the ages of 6 yrs and 75 yrs of age

You may also qualify for participation in SARP as a “comparative” patient with mild asthma.     Similarly, you must be diagnosed with asthma, be between 6 and 75 yrs of age and not be currently smoking or have smoked for more than 5-10 yrs

Website Builder