Severe Asthma Research Program (SARP)
A National Institutes of Health/ National Heart, Lung & Blood Institutes
Our goal is to better understand the changes that occur in the airways of people with severe asthma and what happens to these airways over time. We will be studying adults and children with severe asthma using CT and MRI imaging, along with other measurements of the airways. We will compare what we find with other study subjects that have well- controlled asthma, no airway disease, and people with chronic bronchitis. By studying these changes we hope to identify people with asthma that would benefit from specific targeted therapy. This project will lead to new insights on the mechanistic basis for severe asthma, how it differs from mild-moderate asthma, identify new targets for intervention, and will provide imaging measurements to evaluate outcomes for new asthma treatments.
The Washington University in St. Louis site will include a site for adult participants at Washington University Medical Center (Division of Pulmonary, Allergy and Critical Care Medicine) and a site for children in the division of Pulmonary Medicine, Allergy, and Immunology at St. Louis Children’s Hospital.