Severe Asthma Research Program    (SARP)
A National Institutes of Health/ National Heart, Lung & Blood Institutes
sponsored network

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Wake Forest / Emory Partnership - Information for Asthmatics and caregivers
PARTICIPATE IN SARP  -  WAKE FOREST UNIVERSITY

Variation in an individual’s genes and interaction with their environment contributes to asthma susceptibility, but the clinical and genetic characteristics determining the development of severe asthma are not well understood.  Nor is much known about whether changes such as increased cells causing inflammation in the lungs, repeated asthma attacks (exacerbations), persistent symptoms or other clinical characteristics are important in this process over time.  Individuals who enroll in the SARP study will be comprehensively assessed at entry, including breathing tests (lung function), medical history and physical examination, complete questionnaires, response to bronchoconstrictor (methacholine) and bronchodilator (albuterol) stimulus, medication use, response to intramuscular corticosteroid, and collection of blood, sputum, exhaled breath, urine and DNA samples.  Repeat assessments will be conducted at 1, 2 and 3 years.  Genetic and clinical information will be analyzed to identify those initial characteristics which best predict the development of severe asthma.  The stability of asthma severity over time and which genetic or clinical characteristics are most important in determining asthma severity will be investigated at our site.    

Site Investigator and Locations:



Eugene Bleecker, MD: Principal Investigator
 
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157

Deborah Meyers, PhD; Co-Investigator
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157

Wendy Moore, MD: Co-Investigator
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157

Steve Peters, MD: Co-Investigator
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157

Annette Hastie, PhD; Co-Investigator
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157

Greg Hawkins, PhD; Co-Investigator
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157


Anne Fitzpatrick, PhD; Co-Investigator
Emory University
Atlanta, Georgia 30322 

Site Coordinator Contact:

Wake Forest University

Regina Smith    
Phone: 336-713-8551    
Email: rvsmith@wakehealth.edu

Jeff Krings, NP
Phone: 336-713-9188    
Email: jkrings@wakehealth.edu


Emory University

Jennifer Dodds 
Phone: 404-727-5176
Email: jcdodds@emory.edu

Shaneka Douglas 
Phone: 404-727-7687
Email:
sdougl5@emory.edu


Interested in Participating in SARP?


You will likely qualify for participation in SARP as a severe asthmatic if you:
1.    Have been diagnosed with asthma by a physician
2.    Require high  or continuous doses of asthma medications, such as Advair, Symbicort, prednisone or medrol
3.    Still have asthma symptoms on a regular basis
4.    Have had frequent or severe exacerbations of asthma (requiring prednisone,  ER visits, hospitalizations)
5.    Are not currently smoking and have smoked less than 5-10 years total
6.    Are between the ages of 6 yrs and 75 yrs of age

You may also qualify for participation in SARP as a “comparative” patient with mild asthma.     Similarly, you must be diagnosed with asthma, be between 6 and 75 yrs of age and not be currently smoking or have smoked for more than 5-10 yrs

PARTICIPATE IN SARP UNIVERSITY OF PITTSBURGH
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