​Severe Asthma Research Program
A National Institutes of Health/ National Heart, Lung & Blood Institute sponsored network

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Clinical Clusters & Phenotypes​

1.    Luyster FS, et al. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest. 2016 Dec;150(6):1242-1250. doi: 10.1016/j.chest.2016.09.020. PubMed PMID: 27720882.

Our study found over a third of adults with asthma have insomnia. Those with insomnia had more depression and anxiety, poorer quality of life, and had more frequent asthma-related health care use in the past year than those without insomnia. Patients with asthma should be evaluated for insomnia and provided insomnia treatment if needed by their healthcare provider. 

Insomnia is an inability to get a good night’s sleep on a regular basis . It was found in 37% of adults with asthma. Those with insomnia had more symptoms of depression and anxiety and worse quality of life than those without insomnia. Also, patients who reported insomnia had more frequent doctor visits, emergency room visits, and hospitalizations because of their asthma than those without insomnia. These findings suggest patients with asthma should be asked about sleep problems and provided treatment for insomnia if needed by their doctor.
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2.    Wong-McGrath K, et al.  National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2017 Oct 26. pii: S0012-3692(17)32919-7. doi: 10.1016/j.chest.2017.10.017. [Epub ahead of print] PubMed PMID: 29080709.

Lay Summary: Internet-Based Monitoring Systems (IBS) have the potential to improve understanding of disease behavior, especially in chronic diseases like asthma. In this study we evaluated the usefulness of internet based monitoring as a research tool for monitoring asthma control in patients enrolled in the Severe Asthma Research Program. We found that subject participation with the internet based monitoring tool was influenced by race, socioeconomic status, and asthma control. Among patients that participated with internet based monitoring we identified a sub-group of asthma patients with asthma symptoms that fluctuated significantly throughout the study. These patients with labile asthma control were characterized by an increased susceptibility to cold and flulike illness and a high body mass index.

Conclusion:
- Participation in internet-based monitoring in asthma is influenced by race, socioeconomic status, and asthma control
- Asthma patients with labile asthma control are characterized by an increased susceptibility to develop colds and flulike illness and high rates of obesity.

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​3.    Fitzpatrick AM, et al. Racial disparities in asthma-related healthcare utilization in the National Heart, Lung and Blood Institute’s Severe Asthma Research. 2019 Jan 8. pii: S0091-6749(18)31732-9. doi: 10.1016/j.jaci.2018.11.022. PubMed PMID: 30635198.