​Severe Asthma Research Program
A National Institutes of Health/ National Heart, Lung & Blood Institute sponsored network

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Prescott G. Woodruff, MD, MPH; Co-Investigator
University of California, San Francisco
San Francisco, California 94143-0130

The San Francisco site includes a site for adult and pediatric participants at University of California, San Francisco.

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Our research program aims to uncover disease mechanisms, develop disease biomarkers, and evaluate novel treatments for asthma. Our clinical research is enabled by methods we have optimized for application in human studies to advance knowledge about patterns of airway inflammation and remodeling and about the biophysical and biochemical characteristics of pathologic airway mucus. In bench laboratory studies we focus on mechanisms of epithelial cell dysfunction in asthma, including studies of airway mucus. Mucus pathology is an important cause of airway infection and pathologic mucus plug formation in airway disease. Mucin glycoproteins are a key component of airway mucus, and our lab has a specific interest in how mucin glycans participate in mechanisms of microbial adhesion and abnormal mucus rheology.

Site Investigators:

John Fahy, MD Principal Investigator
University of California
San Francisco, California 94143-0130

Ngoc P. Ly, MD, MPH; Co-Investigator
University of California, San Francisco
Benioff Children’s Hospital
San Francisco, California 94143-0130


Site Coordinators:

University of California, San Francisco,

Adult Project Manager
Donna Liu
Phone: (415) 502-0276
Email: donna.liu@.ucsf.edu 

University of California, San Francisco, Pediatrics
Courtney Moreno
Phone: (415)476-2984

Email: MorenoC@peds.ucsf.edu

U.C. San Francisco